Phenolic Constituents from Phlomis lycia

There are 34 Phlomis L. species (Labiatae) growing in Turkey. Some Phlomis species are used as tonics and stimulants in Anatolia . During our systematic phytochemical investigations of Phlomis species we have studied P. linearis Boiss. & Bal.3−6, Phlomis armeniaca Willd., Phlomis pungens Willd. var. pungens 8−10, Phlomis pungens Willd. var. hirta Velen, Phlomis bourgaei Boiss., and Phlomis longifolia var. longifolia. Investigations on the aerial parts of these plants have resulted in the isolation of phenylethanoid glycosides such as phlinosides A-E , verbascoside (=acteoside), leucosceptoside A, martynoside, forsythoside B7−9,13,14, alyssonoside, leucosceptoside B, hattushoside8−10,12 and iridoid glucosides such as lamiide, ipolamiide, auroside, shanzhiside methyl ester, 5-deoxypulchelloside, lamalbide and phlomiol4−12,14 along with monoterpene glucosides, betulalbuside A and 8-hydroxylinaloyl-3-O-β-D-glucopyranoside with diterpenoids such as jhanol and jhanol acetate . In a continuation of our studies on the glycosidic constituents of Phlomis L. species, we investigated Phlomis lycia further and isolated a lignan glucoside (-)-dihydrodehydrodiconiferyl alcohol-9-O-β-D-glucopyranoside (1), and chlorogenic acid (2), together with three phenylethanoid glycosides, forsythoside B (3), alyssonoside (4) and leucosceptoside B (5). Additionally, two iridoid glucosides, lamiide (6) and auroside (7), were isolated from the same plant.